منابع مشابه
Giant cells in arthritic synovium.
OBJECTIVES Giant cells are commonly present in inflamed synovium, often in close association with the intimal layer. The nature of these multinucleate cells has been reassessed using new cytochemical and immunochemical techniques. METHODS Cryostat sections of non-inflamed, rheumatoid arthritic and osteoarthritic synovia were analysed for the presence of CD68 and non-specific esterase, markers...
متن کاملMolecular weight-dependent effects of hyaluronate on the arthritic synovium.
Intra-articular injection of hyaluronate (HA) is widely used in the treatment of arthropathies. However, the mechanism of the effects of HA preparations on the arthritic synovium and the relationship between their effects and molecular weights (MW) remains unknown. The objectives of this study were to compare the effects of two hyaluronate preparations, HA84 (MW: 84 X 10(4)) and HA230 (MW: 230 ...
متن کاملCharacterization of multinucleated giant cells in synovium and subchondral bone in knee osteoarthritis and rheumatoid arthritis
BACKGROUND Multinucleated giant cells have been noticed in diverse arthritic conditions since their first description in rheumatoid synovium. However, their role in the pathogenesis of osteoarthritis (OA) or rheumatoid arthritis (RA) still remains broadly unknown. We aimed to study the presence and characteristics of multinucleated giant cells (MGC) both in synovium and in subchondral bone tiss...
متن کاملVEGF and CD31 expression in arthritic synovium and cartilage of human knee joints.
PURPOSE To determine the histological differences and the particular aspects of local angiogenesis in knee joint of the patients with osteoarthritis (OA) and rheumatoid arthritis (RA). MATERIALS AND METHODS In 10 cases with RA and five OA, immunohistochemical stains were performed with CD31 and VEGF-A (Vascular Endothelial Growth Factor). All surgical samples provided from total knee joint ar...
متن کاملIncreased expression of human type IIa secretory phospholipase A2 antigen in arthritic synovium.
OBJECTIVE To determine the localisation and level of expression of human type IIa secretory phospholipase A2 (sPLA2) in the synovium of rheumatoid arthritis (RA), osteoarthritis (OA), and non-arthritic (NA) patients and to examine the relation between sPLA2 and histological features of inflammation. METHODS Immunoperoxidase staining using the anti-sPLA2 monoclonal antibody 9C1 was performed o...
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ژورنال
عنوان ژورنال: Annals of the Rheumatic Diseases
سال: 1993
ISSN: 0003-4967
DOI: 10.1136/ard.52.3.182